Buy Sildenafil
Sildenafil citrate is the active ingredient of many drugs to combat erectile dysfunction. Originally proposed as a matter of cardiovascular means, but as it turned Sildenafil citrate was not effective. Some male patients, who received the drug, have noticed increased sexual potency. After such an effect of medical industry professionals have begun research and testing of the drug towards the treatment of erectile problems.
The drug effect on male potency was confirmed, and received a medical Sildenafil citrate used to combat erectile dysfunction. The mechanism of action of a medicinal product is still not fully investigated. If we consider the drug from the perspective of biochemistry, the basic meaning of sildenafil is currently in the ability to selectively inhibit the activity of the enzyme phosphodiesterase type V, which carries the inactivation of cyclic guanosine monophosphate (c-GMP). Guanosine monophosphate, in turn, serves to relax the smooth muscles of the cavernous body and improves blood flow to the penis.
Sildenafil has no direct effect on vascular relaxation of the corpus cavernosum, but increases the effect of vasodilatation, the release of nitric oxide (NO) at the time of sexual stimulation. Physiologically, the substance acts as a spinal cord stimulation. Since then, the drug began to be used to treat disorders of potency associated with lesions of the spinal cord. Sildenafil citrate was an effective tool to combat erectile dysfunction. Dosage form of the drug - pills. When administered rapidly and completely absorbed.
The drug enters the body is subjected to intense biotransformation in the liver and leads to the formation of the active metabolite. In the process of metabolism of the substance excreted from the body. In order to achieve an erection the drug administered orally at a dose of 50 mg 1 hour before the scheduled intercourse. Doses vary depending on the desired effect. The maximum recommended dose is no more than 0.1 g 1 per day. According to available indications, the drug is generally well tolerated. Among the side effects of therapeutic agent are: dizziness, headache, increased peripheral vascular (flushing), indigestion, blurred vision, myalgia, and arthralgia.
There are also contraindications for use. The drug is not recommended in cases of severe medical conditions. Cardiologists pay attention to patients at risk of therapeutic agent in conjunction with nitrates. For patients who suffer from diabetes, endocrinologists recommended to consult with an ophthalmologist and a cardiologist.
